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We modified the open-source diet (Research Diets, D11112201) to reduce dextrose in the diet and replace corn starch with inulin

The graph shows mean percent L1 band intensity (SEM, n = 2 independent experiments) relative to the control group

Interestingly, the reduced levels of PI(4)P and PI(4,5)P 2 in both rod Igf-1r / and ret Igf-1r / mice suggest that IGF-1R may regulate phosphatidylinositol 4-kinase (PI4K generates PI(4)P from PI), phosphatidylinositol 5-phosphate 4-kinase (PIP4K generates PI4,5P 2 from PI(4)P), and phosphatidylinositol 4-phosphate 5-kinase (PIP5K generates PI (4,5)P 2 from PI(5)P)