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PKB/Akt phosphorylates and activates phosphodiesterase 3B, which degrades cAMP in adipocytes, releasing PKA from activation and decreasing lipolysis through a reduction in the phosphorylation-mediated activation of HSL and perilipin

Cobalamin (Vitamin B12) In: Rucker R.B., Suttie J.W., McCormick D.B., Machlin L.J., editors

10.1016/j.cell.2017.02.031 Cell 5 BorodkinaA

The decrease in osmotic pressure due to degeneration may be more conducive to cell proliferation and function, with the NFAT5 signaling pathway playing a key role in mediating osmotic pressure response and differentiation