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ACG clinical guideline: preventive care in inflammatory bowel disease

What the Authoritative Sources Say About B12 Deficiency and Supplementation The National Institutes of Health Office of Dietary Supplements publishes the most thorough citation-backed overview of vitamin B12 its role in red blood cell formation and neurological function, the populations most at risk for deficiency (older adults, people on long-term metformin or proton pump inhibitors, vegetarians and vegans, people who have had gastric bypass surgery), and the recommended daily intake at each life stage

Vitamin B-12 aids the development and maintenance of what is known within medical lingo as the myelin sheath. This is a protective layer formed around the nerves, so when deficiency occurs, this layer can become damaged

As PA without treatment can lead to various symptoms with irreversible neurological sequelae (Table 3), It is recommended to test for IF antibodies in a patient with suspected cobalamin deficiency [3,7,14]

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This is very common in vegetarians and vegans