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Respiratory system : Succinate accumulation and TLR4/ROS signaling promote acute lung injury/acute respiratory distress syndrome (ALI/ARDS) through cytokine storm and alveolar damage

Various studies have demonstrated that patients suffering from diabetes, severe obesity, hypertension and cardiovascular disease are more prone to experiencing unfavorable outcomes following infection with COVID-19 ( 3 Pathogenesis of septic ARDS Sepsis is the most common pathogenic factor of ARDS, which can cause ARDS in less than a week, and the prognosis of those patients is poor ( Figure 1 )

FEBS Lett 589(1):165171

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Mittag, T